Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response, cancer and inflammation, preclinical models, chemotherapy and radiotherapy interactions/combinations of chemotherapy and radiotherapy, and other combination treatments with the anti-tumor immune response.
Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancersKhaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Fabienne Thomas, Marie-Hélène Laverriere, Edouard Girard, Gael Roth, Arnaud Millet
24 September 2024
Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancerRemziye E Wessel, Nardin Ageeb, Joseph M Obeid, Ileana S Mauldin, Kate A Goundry, Gabriel F Hanson, Mahdin Hossain, Chad Lehman, Ryan D Gentzler, Nolan A Wages, Craig L Slingluff, Jr, Timothy N J Bullock, Sepideh Dolatshahi, Michael G Brown
18 September 2024
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signalingFeyza Gül Özbay Kurt, Beatrice-Ana Cicortas, Bianca M Balzasch, Carolina De la Torre, Volker Ast, Ece Tavukcuoglu, Cagla Ak, Sebastian A Wohlfeil, Adelheid Cerwenka, Jochen Utikal, Viktor Umansky
11 September 2024
Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathwayZelin Hou, Fengchun Lu, Jiajing Lin, Yuwei Wu, Linjin Chen, Haizong Fang, Linlin Chen, Shihan Zhang, Heguang Huang, Yu Pan
4 September 2024
NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastomaOlaya de Dios, M Angeles Ramírez-González, Irene Gómez-Soria, Berta Segura-Collar, Juliana Manosalva, Diego Megías, Carlos E De Andrea, Leticia Fernández-Rubio, Aurelio Hernández-Laín, Juan M Sepúlveda-Sánchez, Maria E Rodriguez-Ruiz, Ángel Pérez-Núñez, Derek A Wainwright, Ricardo Gargini, Pilar Sánchez-Gómez
30 August 2024
Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapyPriscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Andreas Ernst, Bernhard Bruene, Andreas Weigert
28 August 2024
ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophagesTao Chen, Jiangang Liu, Chenci Wang, Zhengwei Wang, Jiayi Zhou, Jiani Lin, Jie Mao, Tingzheng Pan, Jianwei Wang, Hongchao Xu, Xiaosheng He, Dinglan Wu, Zhuohao Liu
13 August 2024
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8 T cells and inhibited tumor growthXueyuan Lyu, Linlin Zhao, Sijia Chen, Yulu Li, Yajing Yang, Huisi Liu, Fang Yang, Wenhui Li, Jianhua Sui
13 August 2024
Targeting tumor-associated macrophage-derived CD74 improves efficacy of neoadjuvant chemotherapy in combination with PD-1 blockade for cervical cancerZixiang Wang, Bingyu Wang, Yuan Feng, Jinwen Ye, Zhonghao Mao, Teng Zhang, Meining Xu, Wenjing Zhang, Xinlin Jiao, Qing Zhang, Youzhong Zhang, Baoxia Cui
6 August 2024
Prophylactic IL-23 blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapyMingyi Ju, Jiaojiao Zhang, Zhuoyuan Deng, Minjie Wei, Lianghua Ma, Ting Chen, Lin Zhao
31 July 2024