Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response, cancer and inflammation, preclinical models, chemotherapy and radiotherapy interactions/combinations of chemotherapy and radiotherapy, and other combination treatments with the anti-tumor immune response.
Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinomaRyan P O’Connell, Kevin Liaw, Nils Wellhausen, Christopher A Chuckran, Pratik S Bhojnagarwala, Devivasha Bordoloi, Daniel Park, Nicholas Shupin, Daniel Kulp, Carl H June, David Weiner
4 June 2024
Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer modelZhenqiang Sun, Yanxin Xu, Bo Shao, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chen Chen, Chaoguan Wang, Jinbo Liu, Yang Liu, Junhong Hu
23 May 2024
Colorectal cancer-specific IFNβ delivery overcomes dysfunctional dsRNA-mediated type I interferon signaling to increase the abscopal effect of radiotherapyKevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Pei-Chih Lee, Ji-An Liang, Tao-Wei Ke, Shin-Lei Peng, An‑Cheng Shiau, Tsung-Wei Chen, Pei-Chen Yang, William Tzu-Liang Chen, K S Clifford Chao
15 May 2024
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapyChristopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra GuptaSee the full list of authors
9 May 2024
CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma modelJiyoung Yun, Robert Saddawi-Konefka, Benjamin Goldenson, Riyam Al-Msari, Davide Bernareggi, Jaya L Thangaraj, Shiqi Tang, Sonam H Patel, Sarah M Luna, J Silvio Gutkind, Dan Kaufman
3 May 2024
Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptidesMaria Alejandra Garcia-Marquez, Martin Thelen, Eugen Bauer, Lukas Maas, Kerstin Wennhold, Jonas Lehmann, Diandra Keller, Miloš Nikolić, Julie George, Thomas Zander, Wolfgang Schröder, Philipp Müller, Ali M Yazbeck, Christiane Bruns, Roman ThomasSee the full list of authors
17 April 2024
Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathwayMari Tone, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta, Yoshito Takeda, Yasushi Shintani, Atsushi Kumanogoh, Hisashi Wada
15 April 2024
Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cellsSarah Ducellier, Mélanie Demeules, Boris Letribot, Massimiliano Gaetani, Chloé Michaudel, Harry Sokol, Abdallah Hamze, Mouad Alami, Mégane Nascimento, Sébastien Apcher
11 April 2024
Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responsesBo Wang, Bingkun Zhou, Junyu Chen, Xi Sun, Wenjuan Yang, Tenghao Yang, Hao Yu, Peng Chen, Ke Chen, Xiaodong Huang, Xinxiang Fan, Wang He, Jian Huang, Tianxin Lin
8 April 2024
Blocking senescence and tolerogenic function of dendritic cells induced by γδ Treg cells enhances tumor-specific immunity for cancer immunotherapyFusheng Si, Xia Liu, Yan Tao, Yuanqin Zhang, Feiya Ma, Eddy C Hsueh, Sidharth V Puram, Guangyong Peng
5 April 2024