Section Edited by Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse modelDiana Rose E Ranoa, Preeti Sharma, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother, Edward J RoySee the full list of authors
31 May 2023
Cell surface marker-based capture of neoantigen-reactive CD8 T-cell receptors from metastatic tumor digestsPraveen D Chatani, Frank J Lowery, Neilesh B Parikh, Kyle J Hitscherich, Rami Yossef, Victoria Hill, Jared J Gartner, Biman Paria, Maria Florentin, Satyajit Ray, Alakesh Bera, Maria Parkhust, Paul Robbins, Sri Krishna, Steven A Rosenberg
31 May 2023
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemiaAnil Kumar, Adeleh Taghi Khani, Caroline Duault, Soraya Aramburo, Ashly Sanchez Ortiz, Sung June Lee, Anthony Chan, Tinisha McDonald, Min Huang, Norman J. Lacayo, Kathleen M. Sakamoto, Jianhua Yu, Christian Hurtz, Martin Carroll, Sarah K. TasianSee the full list of authors
22 May 2023
CAR T-cell detection scoping review: an essential biomarker in critical need of standardizationDavid P Turicek, Victoria M Giordani, Josquin Moraly, Naomi Taylor, Nirali N Shah
22 May 2023
Use of cytokine-induced killer cell therapy in patients with colorectal cancer: a systematic review and meta-analysisCeline Man Ying Li, Yoko Tomita, Bimala Dhakal, Runhao Li, Jun Li, Paul Drew, Timothy Price, Eric Smith, Guy J Maddern, Kevin Aaron Fenix
28 April 2023
Severe cytopenia after CD19 CAR T-cell therapy: a retrospective study from the EBMT Transplant Complications Working PartyOlaf Penack, Christophe Peczynski, Christian Koenecke, Emmanuelle Polge, Andrea Kuhnl, Nathalie Fegueux, Michael Daskalakis, Nicolaus Kröger, Peter Dreger, Caroline Besley, Urs Schanz, Adrian Bloor, Arnold Ganser, Edouard Forcade, Lucia López CorralSee the full list of authors
18 April 2023
Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosisAna Belen Moreno-Castaño, Sara Fernández, Helena Ventosa, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Valentín Ortiz-Maldonado, Julio Delgado, Carlos Fernández de Larrea, Alvaro Urbano-Ispizua, Olaf Penack, J M Nicolás, Adrian Téllez, Gines Escolar, Enric CarrerasSee the full list of authors
12 April 2023
Specific recognition of an FGFR2 fusion by tumor infiltrating lymphocytes from a patient with metastatic cholangiocarcinomaBradley Sinclair White, Sivasish Sindiri, Victoria Hill, Billel Gasmi, Shirley Nah, Jared J Gartner, Todd D Prickett, Yong Li, Devikala Gurusamy, Paul Robbins, Steven A Rosenberg, Vid Leko
12 April 2023
Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locusSangjoon Lah, Segi Kim, In Kang, Hyojin Kim, Cedric Hupperetz, Hyuncheol Jung, Hyeong Ryeol Choi, Young-Ho Lee, Hyeon-Ki Jang, Sangsu Bae, Chan Hyuk Kim
5 April 2023
Serpin B9 controls tumor cell killing by CAR T cellsThomas Kimman, Anne Slomp, Anne Martens, Sarah Grabherr, Shuang Li, Eline van Diest, Jan Meeldijk, Jurgen Kuball, Monique C Minnema, Eric Eldering, Niels Bovenschen, Zsolt Sebestyén, Victor Peperzak
17 March 2023