Section Edited by Aude Chapuis, MD and Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1Tri Minh Tran, Bal Krishna Chand Thakuri, Saule Nurmukhambetova, Jia-Jye Lee, Peirong Hu, Ngoc Q Tran, Brittany Steimle, Pradyot Dash, Dina Schneider
12 April 2024
Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16Nicholas P Casey, Katrin Kleinmanns, Christopher Forcados, Pascal F Gelebart, Sandy Joaquina, Martine Lode, Emmanuelle Benard, Fatemeh Kaveh, Benjamin Caulier, Christiane Helgestad Gjerde, Elvira García de Jalón, David J Warren, Kristina Lindemann, Erik Rokkones, Ben DavidsonSee the full list of authors
11 April 2024
PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustionWanyan Ouyang, Shi-Wei Jin, Nan Xu, Wei-Yang Liu, Han Zhao, Liuqingqing Zhang, Liqing Kang, Yi Tao, Yuanfang Liu, Yan Wang, Jin Wang, Feng Liu, Lei Yu, Zhiqiang Liu, Jian-Qing Mi
8 April 2024
Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AMLVania Lo Presti, Angelo Meringa, Ester Dunnebach, Alice van Velzen, Aida Valera Moreira, Ronald W Stam, Rishi S Kotecha, Anja Krippner-Heidenreich, Olaf T Heidenreich, Maud Plantinga, Annelisa Cornel, Zsolt Sebestyen, Jurgen Kuball, Niek P van Til, S Nierkens
5 April 2024
Safety and efficacy of SNK01 (autologous natural killer cells) in combination with cytotoxic chemotherapy and/or cetuximab after failure of prior tyrosine kinase inhibitor in non-small cell lung cancer: non-clinical mouse model and phase I/IIa clinical studyMyeong Geun Choi, Gun Woo Son, Mi Young Choi, Jae Seob Jung, Jin Kyung Rho, Wonjun Ji, Byeong Gon Yoon, Jong-Min Jo, Yong Man Kim, Dae-Hyun Ko, Jae Cheol Lee, Chang-Min Choi
27 March 2024
Cost-effectiveness of treating advanced melanoma with tumor-infiltrating lymphocytes based on an international randomized phase 3 clinical trialRenske M T ten Ham, Maartje W Rohaan, Inge Jedema, Rob Kessels, Wim Stegeman, Walter Scheepmaker, Bastiaan Nuijen, Cynthia Nijenhuis, Melanie Lindenberg, Troels Holz Borch, Tine Monberg, Marco Donia, Inge Marie Svane, Wim van Harten, John HaanenSee the full list of authors
26 March 2024
Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1Annelisa M. Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Ester Dunnebach, Marliek van Hoesel, Thomas A Kluiver, Ana P Lopes, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Denise A M H van den Beemt, Juliane L Buhl, Aimee du Chatinier, Farnaz BarnehSee the full list of authors
21 March 2024
Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG miceShahryar Khoshtinat Nikkhoi, Ge Yang, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Mohammad Massumi, Arash Hatefi
15 March 2024
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulationJiri Eitler, Wiebke Rackwitz, Natalie Wotschel, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann, Michael BachmannSee the full list of authors
27 February 2024
Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasisSarah L Ash, Rebecca Orha, Holly Mole, Meg Dinesh-Kumar, Steven P Lee, Frances K Turrell, Clare M Isacke
27 February 2024