Section Edited by Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid–lymphoid representation with limited graft-versus-host diseaseCarla Panisello, Rosario Aschero, Alba Martinez-Moreno, Heleia Roca Ho, Aida Falgas, Europa Azucena González-Navarro, Julieta Carabelli, Edwards Pradenas, María Lázaro-Díez, Julia G Prado, Julià Blanco, Jorge Carrillo, Manel Juan, Ángel M Carcaboso, Clara BuenoSee the full list of authors
7 October 2024
Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cellsChangsong Qi, Dongqun Liu, Chang Liu, Xiaofei Wei, Mingyang Ma, Xinan Lu, Min Tao, Cheng Zhang, Xicheng Wang, Ting He, Jian Li, Fei Dai, Yanping Ding, Lin Shen
4 October 2024
Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapyJessie S Kroonen, Anne K Wouters, Ilona J de Graaf, Dennis F G Remst, Sumit Kumar, Tassilo L A Wachsmann, Amina F A S Teunisse, Jessica P Roelands, Noel F C C de Miranda, Marieke Griffioen, Mirjam H M Heemskerk, Alfred C O Vertegaal
26 September 2024
Neurofilament light chain levels as an early predictive biomarker of neurotoxicity after CAR T-cell therapyMarion Larue, Amélie Bouvier, Alexis Maillard, Alexis Cuffel, Vincent Allain, Renata Ursu, Antoine F Carpentier, Elie Azoulay, Catherine Thieblemont, Roberta Di Blasi, Sophie Caillat-Zucman
24 September 2024
BCMA-BBZ-OX40 CAR-T Therapy Using an Instant Manufacturing Platform in Multiple MyelomaTing Wang, Yazi Yang, Lie Ma, Ru Feng, Jiangtao Li, Chunli Zhang, Jiefei Bai, Yanping Ding, Guanghua Liu, Fei Wu, Xinan Lu, Shi Feng, Zhenling Li, Ting He, Jian LiSee the full list of authors
23 September 2024
Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapyWen Luo, Hai Hoang, Hongwen Zhu, Katherine Miller, Xiaokui Mo, Shiori Eguchi, Meijuan Tian, Yanling Liao, Janet Ayello, Jeremy M Rosenblum, Mario Marcondes, Mark Currier, Elaine Mardis, Timothy Cripe, Dean LeeSee the full list of authors
12 September 2024
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirusStefan Barisic, Elizabeth M Brahmbhatt, Elena Cherkasova, Timothy T Spear, Ujjawal Savani, Stephanie Pierre, Gina M Scurti, Long Chen, Muna Igboko, Rosa Nadal, Gang Zeng, Gordon Parry, David F Stroncek, Steven Highfill, Annika V DalheimSee the full list of authors
11 September 2024
Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapyCongwen Wang, Lewei He, Jing Peng, Chong Lu, Meng Zhang, Xingling Qi, Mingxing Zhang, Yumeng Wang
28 August 2024
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumorsKensuke Nakagawara, Makoto Ando, Tanakorn Srirat, Setsuko Mise-Omata, Taeko Hayakawa, Minako Ito, Koichi Fukunaga, Akihiko Yoshimura
16 August 2024
EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responsesLeesa Lertsumitkul, Melinda Iliopoulos, Stacie S Wang, Sarah J McArthur, Lisa M Ebert, Alexander J Davenport, Raelene Endersby, Jordan R Hansford, Katharine J Drummond, Ryan Cross, Misty R Jenkins
7 August 2024