Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathwayXiaoying Wei, Hong Wang, Huiquan Liu, Jianguo Wang, Peijie Zhou, Xiaoyang Li, Yuan He, Yan Li, Dong Han, Ting Mei, Yuwen Wang, Ziye Li, Junhao Ning, Zilong Xu, Anlin WangSee the full list of authors
7 January 2025
Differential impact of TIM-3 ligands on NK cell functionJuncheng Wang, Housaiyin Li, Aditi Kulkarni, Jennifer L Anderson, Pragati Upadhyay, Onyedikachi Victor Onyekachi, Lidia M R B Arantes, Hridesh Banerjee, Lawrence P Kane, Xin Zhang, Tullia C Bruno, Riyue Bao, Robert L Ferris, Lazar Vujanovic
7 January 2025
Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockersYang Lu, Jiamin Gao, Yachen Hou, Han Yang, Dashuai Wang, Ge Zhang, Zhen Qin, Pengchong Du, Zhenwei Wang, Yunzhe Wang, Quanzhou Chen, Zhaowei Sun, Ping Li, Jinying Zhang, Junnan Tang
7 January 2025
Anti-PD-1 amplifies costimulation in melanoma-infiltrating T1-like Foxp3 regulatory T cells to alleviate local immunosuppressionMikhaël Attias, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Fan Huang, Abrahim Sleiman, Tamiko Nishimura, Sonia V del Rincón, Yasser Riazalhosseini, Ciriaco A Piccirillo
6 January 2025
Adenoviral-vectored neoantigen vaccine augments hyperexpanded CD8 T cell control of tumor challenge in miceGabriel Dagotto, Alessandro Colarusso, Robert C Patio, David Li, Tochi Anioke, Victoria Giffin, Ruoran Guan, Trisha Anand, Esther Mbiwan, Malika Aid, Dan Barouch
18 December 2024
METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancerLing Wu, Rui Bai, Yujie Zhang, Hao Chen, Jianghua Wu, Zetao Chen, Hui Wang, Liang Zhao
9 December 2024
Natural lung-tropic T9 cells: a sharp weapon for established lung metastasesTao Chen, Chenxiao Qiao, Eloy Yinwang, Shengdong Wang, Xuehuan Wen, Yixuan Feng, Xiangang Jin, Shuming Li, Yucheng Xue, Hao Zhou, Wenkan Zhang, Xianchang Zeng, Zenan Wang, Hangxiang Sun, Lifeng JiangSee the full list of authors
4 December 2024
Differential predictive value of resident memory CD8T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapyLéa Paolini, Thi Tran, Stéphanie Corgnac, Jean-Philippe Villemin, Marie Wislez, Jennifer Arrondeau, Ludger Johannes, Jonathan Ulmer, Louis-Victorien Vieillard, Joséphine Pineau, Alain Gey, Valentin Quiniou, Pierre Barennes, Hang Phuong Pham, Nadège GruelSee the full list of authors
3 December 2024
N-terminal acetylation of transcription factor LIP induces immune therapy resistance via suppression of PD-L1 expression in non-small cell lung cancerXiang He, Yongshuo Liu, Xing Gao, Feiyu Tang, Yuxi Tian, Siyuan Gong, Jia Shen, Aimin Wang, Lunquan Sun, Wensheng Wei, Liang Weng
29 November 2024
Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinomaSiyu Xia, Lihua Chen, Min Yu, Jiana Li, Jiaxin Chen, Fei Xu, Mengdong Ni, Chaohua Liu, Xiaohua Wu, Xiaojun Chen, Jiajia Li
27 November 2024