Section Edited by Claudia Palena, PhD, Walter Storkus, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Immunosuppressive microenvironment of liver restrains chemotherapeutic efficacy in triple-negative breast cancerMingduo Liu, Mengjia Qian, Wen Sun, Xiaowei Sun, Yue Sun, Muxin Yu, Xinyu Tang, Xinrui Mao, Chang Sun, Qi Qi, Weiya Zhang, Peiwen Ling, Zheng Pang, Wei Li, Hong PanSee the full list of authors
6 March 2025
PD-1 promotes tumor evasion via deregulating CD8 T cell functionHaojing Zang, Tongfeng Liu, Xiaodong Wang, Shuwen Cheng, Xiaofeng Zhu, Chang Huang, Liqiang Duan, Xujie Zhao, Fang Guo, Xuetong Wang, Chang Zhang, Facai Yang, Yinmin Gu, Hongbo Hu, Shan Gao
6 March 2025
Enhanced thrombopoiesis supplies PD-L1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancerSung-Woo Lee, Saei Jeong, Young Ju Kim, Jeong Eun Noh, Kyung Na Rho, Hee-Ok Kim, Hyun-Ju Cho, Deok Hwan Yang, Eu Chang Hwang, Woo Kyun Bae, Sook Jung Yun, Ju Sik Yun, Cheol-Kyu Park, In-Jae Oh, Jae-Ho Cho
26 February 2025
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancerLisha Li, Lei Zhao, Diwei Zhou, Yuanhang Yu, Peiyi Zhang, Jinge Zheng, Zhenyu Lin, Dandan Yu, Jinghua Ren, Jing Zhang, Pengfei Zhou, Dejun Zhang, Tao Zhang
25 February 2025
Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinomaMuqi Liu, Linzhe Li, Lu Cao, Wei Li, Xingshi Gu, Min Yang, Di Wu, Yanan Li, Yao Deng, Juan Zhang, Cejun Yang, Qi Liang, Huaping Liu, Pengfei Rong, Xiaoqian MaSee the full list of authors
23 February 2025
Ethanol inhibits the growth and metastasis of hepatocellular carcinoma by inducing immunogenic cell deathYu-Chen Hsu, Meng-Chuan Wu, Meng Tzu Weng, Ying-Te Lee, Huei-Chi Chou, Hsuan-Shu Lee, Li-Fang Wang, Jin-Chuan Sheu, Chien-Hung Chen
20 February 2025
Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancerAlice Talpin, Ana Maia, Jean-Marie Carpier, Guillaume Kulakowski, Lucie Aubergeon, Jerome Kervevan, Camille Gaal, Francesco Strozzi, Coline Billerey, Ludivine Amable, Tifanny Mersceman, Alexandrine Garnier, Càtia Oliveira, Carolina Calderon, Diana BachroucheSee the full list of authors
20 February 2025
CD56 cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cellsMaria L Guevara Lopez, Ann Gebo, Monica Parodi, Stefano Persano, Josephine Maus-Conn, Maria Cristina Mingari, Fabrizio Loiacono, Paola Orecchia, Simona Sivori, Claudia Cantoni, Marco Gentili, Federica Facchinetti, Riccardo Ferracini, Daniel A Vallera, Martin FelicesSee the full list of authors
12 February 2025
Arginase-1-specific T cells target and modulate tumor-associated macrophagesEvelina Martinenaite, Inés Lecoq, Mia Aaboe-Jørgensen, Shamaila Munir Ahmad, Maria Perez-Penco, Hannah Jorinde Glöckner, Marion Chapellier, Lucía Lara de la Torre, Lars Rønn Olsen, Anne Mette Askehøj Rømer, Ayako Wakatsuki Pedersen, Mads Hald Andersen
29 January 2025
Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanomaRotem Leshem, Kieran Neil Sefton, Chun Wai Wong, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone
27 January 2025