Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancerKelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M de Winde, Ernesto Rodriguez, Dimitri Lindijer, Babet Springer, Irene van der Haar Àvila, Aram de Haas, Laetitia Wehry, Louis Boon, Reina E Mebius, Nadine van Montfoort, Manfred Wuhrer, Joke M M den HaanSee the full list of authors
8 November 2023
Quantifying the impact of immunotherapy on RNA dynamics in cancerIeva Usaite, Dhruva Biswas, Krijn Dijkstra, Thomas BK Watkins, Oriol Pich, Clare Puttick, Mihaela Angelova, Krupa Thakkar, Crispin Hiley, Nicolai Birkbak, Marleen Kok, Simone Zaccaria, Yin Wu, Kevin Litchfield, Charles SwantonSee the full list of authors
1 November 2023
Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathwayJing Zhang, Hui Dai, Lei Huo, Jared K Burks, Daniel J McGrail, Shiaw-Yih Lin
31 October 2023
Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor modelsGerwin Gerhard Wemke Sandker, Jim Middelburg, Evienne Wilbrink, Janneke Molkenboer-Kuenen, Erik Aarntzen, Thorbald van Hall, Sandra Heskamp
29 October 2023
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancerCristina Travelli, Giorgia Colombo, Martina Aliotta, Francesca Fagiani, Natalia Fava, Rita De Sanctis, Ambra A Grolla, Joe G N Garcia, Nausicaa Clemente, Paola Portararo, Massimo Costanza, Fabrizio Condorelli, Mario Paolo Colombo, Sabina Sangaletti, Armando A Genazzani
25 October 2023
MCT4 blockade increases the efficacy of immune checkpoint blockadeNathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Roberta Ferretti, Clarissa Korf, Christian Schmidl, Lisa Schmidleithner, Benedikt Nerb, Carina Matos, Gudrun E Koehl, Peter Siska, Christina Bruss, Fabian KellermeierSee the full list of authors
25 October 2023
Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunitySabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant, Victoria A Brentville
19 October 2023
Asymmetric anti-CLL-1×CD3 bispecific antibody, ABL602 2+1, with attenuated CD3 affinity endows potent antitumor activity but limited cytokine releaseEunhee Lee, Shinai Lee, Sumyeong Park, Yong-Gyu Son, Jiseon Yoo, Youngil Koh, Dong-Yeop Shin, Yangmi Lim, Jonghwa Won
17 October 2023
C-reactive protein impairs immune response of CD8 T cells via FcγRIIb-p38MAPK-ROS axis in multiple myelomaJinxing Jiang, Ziyi Peng, Junying Wang, Mengping Chen, Yike Wan, Honghui Huang, Zhiqiang Liu, Jingya Wang, Jian Hou
16 October 2023
SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical modelsElizabeth Gray, Michelle Ulrich, Angela Epp, Patrick Younan, Disha Sahetya, Kelly Hensley, Sean Allred, Li-Ya Huang, Julie Hahn, Kristen Gahnberg, Piper M Treuting, Esther S Trueblood, John J Gosink, Robert Thurman, Serena WoSee the full list of authors
4 October 2023
