Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanomaQian Zhong, Hongying Hao, Shu Li, Yongling Ning, Hong Li, Xiaoling Hu, Kelly M McMasters, Jun Yan, Chuanlin Ding
27 November 2024
Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progressionAmaia Martinez-Usatorre, Laura Ciarloni, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Eric Durandau, Sylvain Monnier-Benoit, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Mauro Delorenzi, Stephan Morgenthaler, Brian Hashemi, Noushin HadadiSee the full list of authors
21 November 2024
TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustionAnais Debesset, Caroline Pilon, Sylvain Meunier, Orianne Cuelenaere-Bonizec, Wilfrid Richer, Allan Thiolat, Claire Houppe, Matteo Ponzo, Jeanne Magnan, Jonathan Caron, Pamela Caudana, Jimena Tosello Boari, Sylvain Baulande, Nhu Han To, Benoit Laurent SalomonSee the full list of authors
19 November 2024
YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrixJingchao Bai, Meinan Yan, Yihan Xu, Youhui Wang, Yuan Yao, Peng Jin, Yuhan Zhang, Yang Qu, Liling Niu, Hui Li
17 November 2024
Inhibition of Cbl-b restores effector functions of human intratumoral NK cellsSofia Tundo, Marcel Trefny, Andrijana Rodić, Olivia Grueninger, Nicole Brodmann, Anastasiya Börsch, Clara Serger, Jonas Fürst, Melanie Buchi, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Petra Herzig, Didier LardinoisSee the full list of authors
17 November 2024
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinomaLisa A McIlvried, Andre A Martel Matos, Mona M Yuan, Megan A Atherton, Fendi Obuekwe, Marci L Nilsen, Amin Reza Nikpoor, Sebastien Talbot, Tullia C Bruno, David N Taggart, Lorin K Johnson, Robert L Ferris, Dan P Zandberg, Nicole N Scheff
17 November 2024
FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinomaJunshang Ge, Ying Liu, Pan Chen, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Mei Yi, Bo Xiang
14 November 2024
Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expressionMalte Roerden, Andrea B Castro, Yufei Cui, Noora Harake, Byungji Kim, Jonathan Dye, Laura Maiorino, Forest M White, Darrell J Irvine, Kevin Litchfield, Stefani Spranger
9 November 2024
Bendamustine–rituximab elicits dual tumoricidal and immunomodulatory responses via cGAS–STING activation in diffuse large B-cell lymphomaRuipei Xiao, Wenli Zhao, Wei Lin, Yudian Xiao, Jie Ren, Yang Zhou, Wei Meng, Enguang Bi, Ling Jiang
9 November 2024
Depletion of conventional CD4 T cells is required for robust priming and dissemination of tumor antigen-specific CD8 T cells in the setting of anti-CD4 therapyDelaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, Tiffany Chen, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Keisuke Shirai, Joseph D Phillips, Pamela C Rosato, Yina H Huang, Mary Jo Turk
9 November 2024