Section Edited by Claudia Palena, PhD, Walter Storkus, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancerLing Wu, Rui Bai, Yujie Zhang, Hao Chen, Jianghua Wu, Zetao Chen, Hui Wang, Liang Zhao
9 December 2024
Natural lung-tropic T9 cells: a sharp weapon for established lung metastasesTao Chen, Chenxiao Qiao, Eloy Yinwang, Shengdong Wang, Xuehuan Wen, Yixuan Feng, Xiangang Jin, Shuming Li, Yucheng Xue, Hao Zhou, Wenkan Zhang, Xianchang Zeng, Zenan Wang, Hangxiang Sun, Lifeng JiangSee the full list of authors
4 December 2024
Differential predictive value of resident memory CD8T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapyLéa Paolini, Thi Tran, Stéphanie Corgnac, Jean-Philippe Villemin, Marie Wislez, Jennifer Arrondeau, Ludger Johannes, Jonathan Ulmer, Louis-Victorien Vieillard, Joséphine Pineau, Alain Gey, Valentin Quiniou, Pierre Barennes, Hang Phuong Pham, Nadège GruelSee the full list of authors
3 December 2024
N-terminal acetylation of transcription factor LIP induces immune therapy resistance via suppression of PD-L1 expression in non-small cell lung cancerXiang He, Yongshuo Liu, Xing Gao, Feiyu Tang, Yuxi Tian, Siyuan Gong, Jia Shen, Aimin Wang, Lunquan Sun, Wensheng Wei, Liang Weng
29 November 2024
B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanomaQian Zhong, Hongying Hao, Shu Li, Yongling Ning, Hong Li, Xiaoling Hu, Kelly M McMasters, Jun Yan, Chuanlin Ding
27 November 2024
Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinomaSiyu Xia, Lihua Chen, Min Yu, Jiana Li, Jiaxin Chen, Fei Xu, Mengdong Ni, Chaohua Liu, Xiaohua Wu, Xiaojun Chen, Jiajia Li
27 November 2024
Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progressionAmaia Martinez-Usatorre, Laura Ciarloni, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Eric Durandau, Sylvain Monnier-Benoit, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Mauro Delorenzi, Stephan Morgenthaler, Brian Hashemi, Noushin HadadiSee the full list of authors
21 November 2024
TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustionAnais Debesset, Caroline Pilon, Sylvain Meunier, Orianne Cuelenaere-Bonizec, Wilfrid Richer, Allan Thiolat, Claire Houppe, Matteo Ponzo, Jeanne Magnan, Jonathan Caron, Pamela Caudana, Jimena Tosello Boari, Sylvain Baulande, Nhu Han To, Benoit Laurent SalomonSee the full list of authors
19 November 2024
Inhibition of Cbl-b restores effector functions of human intratumoral NK cellsSofia Tundo, Marcel Trefny, Andrijana Rodić, Olivia Grueninger, Nicole Brodmann, Anastasiya Börsch, Clara Serger, Jonas Fürst, Melanie Buchi, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Petra Herzig, Didier LardinoisSee the full list of authors
17 November 2024
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinomaLisa A McIlvried, Andre A Martel Matos, Mona M Yuan, Megan A Atherton, Fendi Obuekwe, Marci L Nilsen, Amin Reza Nikpoor, Sebastien Talbot, Tullia C Bruno, David N Taggart, Lorin K Johnson, Robert L Ferris, Dan P Zandberg, Nicole N Scheff
17 November 2024