Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancerHyein Jeong, Jaemoon Koh, Sehui Kim, Jeemin Yim, Seung Geun Song, Hanbyeol Kim, Yingying Li, Soo Hyun Lee, Yeon Kyu Chung, Hongsoon Kim, Chul-Hwan Lee, Hye Young Kim, Bhumsuk Keam, Se-Hoon Lee, Doo Hyun ChungSee the full list of authors
6 March 2025
Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective studyAmin H Nassar, Sarah Abou Alaiwi, Talal El Zarif, Ryan Denu, Walid Macaron, Noha Abdel-Wahab, Dory Freeman, Alexi Vasbinder, Salim Hayeck, Elizabeth Anderson, Rachel S Goodman, Douglas B Johnson, Shirly Grynberg, Ronnie Shapira, Jennifer M KwanSee the full list of authors
3 March 2025
Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axisChenyue Wang, Lisha Wu, Xingxing Li, Shuyang Mao, Zitong Wang, Haiyan Xie, Jing Xu, Danfang Li, Hao Yang, Tong Wang, Qingqing Huang, Lin Yang, Xiaofei Zhang, Yuxia Liu, Jin WangSee the full list of authors
27 February 2025
T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab followed by standard neoadjuvant chemotherapyHarry D Bear, Xiaoyan Deng, Dipankar Bandyopadhyay, Michael Idowu, Taylor M Jenkins, Maciej Kmieciak, Monique Williams, Giovanni Archer, Lindsey Gwaltney, Patrick Dillon, Daniel Flora, Daniel Stover, Andrew S Poklepovic, Mary Hackney, Masey RossSee the full list of authors
27 February 2025
Phase I study of ribociclib (CDK4/6 inhibitor) with spartalizumab (PD-1 inhibitor) with and without fulvestrant in metastatic hormone receptor-positive breast cancer or advanced ovarian cancerAna C Garrido-Castro, Noah Graham, Lestat R Ali, Christina Herold, Jennifer Desrosiers, Khanh Do, Heather Parsons, Tianyu Li, Shom Goel, Molly DiLullo, Eileen Wrabel, Amy J Williams, Joyce F Liu, Elizabeth A Mittendorf, Stephanie K DouganSee the full list of authors
25 February 2025
Corticosteroid premedication on anti-tumor effect of immune checkpoint blockade in murine hepatocellular carcinoma modelsYing-Chun Shen, Nai-Wen Chang, Ching-Ping Yeh, Wan-Ying Lin, Ming-Feng Wei, Da-Liang Ou, Chia-Lang Hsu, Ann-Lii Cheng
20 February 2025
Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutationFei Sun, Fangzhen Yao, Chunting Zeng, Yang Zhao, Bishan Liang, Shaowei Li, Yawen Wang, Qijing Wu, Yulu Shi, Zhiqi Yao, Jiao Wang, Yu Jiang, Chunhui Gu, Qiong Huang, Wangjun LiaoSee the full list of authors
13 February 2025
Efficacy and safety of nivolumab plus ipilimumab in patients with metastatic variant histology (non-clear cell) renal cell carcinomaMohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Kiran L Malikayil, Devaki Shilpa Surasi, Tharakeswara K Bathala, Yiyun Lin, Priya Rao, Pheroze Tamboli, Kanishka Sircar, Helen Ajufo, Khaled M Elsayes, Amishi Shah, Andrew C Johns, Sangeeta GoswamiSee the full list of authors
12 February 2025
4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor modelsEneko Garate-Soraluze, Irantzu Serrano-Mendioroz, Leticia Fernández-Rubio, Carlos E De Andrea, Celia Barrio-Alonso, Claudia del Pilar Herrero, Alvaro Teijeira, Carlos Luri-Rey, Christina Claus, Tamara Tanos, Christian Klein, Pablo Umana, Antonio Rullan, Jon Ander Simón, María CollantesSee the full list of authors
11 February 2025
TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trialAung Naing, Meredith McKean, Anthony Tolcher, Anja Victor, Ping Hu, Wei Gao, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland, Emilia Richter, Keyvan Tadjalli-Mehr, Lillian L Siu
10 February 2025