Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Correlation of safety and efficacy of atezolizumab therapy across indicationsGonzalo Durán-Pacheco, G Scott Chandler, Vidya Maiya, Mark A Socinski, Guru Sonpavde, Javier Puente, Laurent Essioux, Corey Carter, Jose Vicente Cardona, Rajat Mohindra, Jarushka Naidoo
12 November 2024
TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunctionDavid W Vredevoogd, Georgi Apriamashvili, Pierre L Levy, Sanju Sinha, Zowi R Huinen, Nils L Visser, Beaunelle de Bruijn, Julia Boshuizen, Susan E van Hal-van Veen, Maarten A Ligtenberg, Onno B Bleijerveld, Chun-Pu Lin, Judit Díaz-Gómez, Santiago Duro Sánchez, Ettai MarkovitsSee the full list of authors
7 November 2024
Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid culturesJulijan Kabiljo, Anna Theophil, Jakob Homola, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Johannes Laengle, Askin Kulu, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver PuschSee the full list of authors
4 November 2024
Reporting of late-onset immune-related adverse events with immune checkpoint inhibitors in VigiBaseRoberta Noseda, Francesca Bedussi, Valentina Giunchi, Michele Fusaroli, Emanuel Raschi, Alessandro Ceschi
3 November 2024
Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacySantiago Acero-Bedoya, Emily F Higgs, Anna C Martinez, Ruxandra Tonea, Thomas F Gajewski
26 October 2024
Comparison of zuberitamab plus CHOP versus rituximab plus CHOP for the treatment of drug-naïve patients diagnosed with CD20-positive diffuse large B-cell lymphoma: a phase 3 trialZhiming Li, Wenqi Jiang, Hui Zhou, Hong Cen, Mingzhi Zhang, Fangfang Lv, Qingyuan Zhang, Xiuhua Sun, Lihong Liu, Yunhong Huang, Haiyan Yang, Sujun Gao, Chuan He, Wei Yang, Wenyu LiSee the full list of authors
24 October 2024
Targeting CDCP1 boost CD8+ T cells-mediated cytotoxicity in cervical cancer via the JAK/STAT signaling pathwayHua Huang, Yuwen Pan, Qiuwen Mai, Chunyu Zhang, Qiqiao Du, Yuandong Liao, Shuhang Qin, Yili Chen, Jiaming Huang, Jie Li, Tianyu Liu, Qiaojian Zou, Yijia Zhou, Li Yuan, Wei WangSee the full list of authors
24 October 2024
VHL missense mutation delineate aggressive clear cell renal cell carcinoma subtype with favorable immunotherapeutic responseZiyang Xu, Li Liu, Wenbin Jiang, Youqi Qiu, Boyu Zhang, Jiangting Cheng, Jiyan Luo, Jianming Guo, Jiejie Xu
23 October 2024
Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer modelsKellsye P Fabian, Ginette Santiago-Sanchez, Michelle R Padget, Wiem Lassoued, Clint Tanner Allen, Sailaja Battula, Howard Kaufman, James W Hodge
23 October 2024
Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancerNicolas Zhou, Cheuk H Leung, William N William, Jr, Annikka Weissferdt, Apar Pataer, Myrna C B Godoy, Brett W Carter, Frank V Fossella, Anne S Tsao, George R Blumenschein, Xiuning Le, Jianjun Zhang, Ferdinandos Skoulidis, Jonathan M KurieSee the full list of authors
23 October 2024