Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitorsWei Xiong, Liuling Xiao, Rui Duan, Qiang Wang, Miao Xian, Chuanchao Zhang, Pan Su, Yabo LI, Ling Zhong, Jianfei Qian, Chengyun Zheng, Qing Yi
4 January 2025
Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitorsJulien Taieb, Margherita Ambrosini, Emily Alouani, Sara Lonardi, Frank A Sinicrope, Marie Decraecker, Alice Boileve, Emilie Hafliger, Thibault Mazard, Simon Pernot, Pauline Parent, Javier Ros, Michael J Overman, Priya Jayachandran, Vincenzo NascaSee the full list of authors
4 January 2025
Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findingsBrian S Henick, Peter D Koch, Justin F Gainor, Mark M Awad, Codruta Chiuzan, Stephanie Izard, Yohanna Georgis, Samyukta Mallick, Robert F Garofano, Cheryl V Wong, Anjali Saqi, Jessica Grindheim, Katja Schulze, Joshua R Sonett, Naiyer A RizviSee the full list of authors
25 December 2024
Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitisRyosuke Matsukane, Shoji Nakamura, Haruna Minami, Kazuya Tsubouchi, Yasuto Yoneshima, Kojiro Hata, Sai Yasukochi, Kimitaka Suetsugu, Isamu Okamoto, Takeshi Hirota
22 December 2024
Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLCYachang Huo, Dan Wang, Shuangning Yang, Yujie Xu, Guohui Qin, Chenhui Zhao, Qingyang Lei, Qitai Zhao, Yaqing Liu, Kaiyuan Guo, Songyun Ouyang, Ting Sun, Hongmin Wang, Feifei Fan, Na HanSee the full list of authors
19 December 2024
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitmentNils Hansen, Pablo Peña-Martínez, Petter Skoog, Katrin Reinbach, Finja C Hansen, Susanne Larsson Faria, Caitríona Grönberg, Kawther Abdilleh, Susanne Magnusson, Karin von Wachenfeldt, Camilla Rydberg Millrud, David Liberg, Marcus Järås
18 December 2024
LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancerLiting Lv, Qing Miao, Sutong Zhan, Peilin Chen, Wei Liu, Jiawen Lv, Wenjie Yan, Dong Wang, Hongbing Liu, Jie Yin, Jian Feng, Yong Song, Mingxiang Ye, Tangfeng Lv
18 December 2024
Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8CD69 T cellsShichuan Tang, Ruijing Tang, Geng Chen, Da Zhang, Kongying Lin, Huan Yang, Jun Fu, Yutong Guo, Fangzhou Lin, Xiuqing Dong, Tingfeng Huang, Jie Kong, Xiaowei Yin, Aimin Ge, Qizhu LinSee the full list of authors
18 December 2024
Multiomics reveals tumor microenvironment remodeling in locally advanced gastric and gastroesophageal junction cancer following neoadjuvant immunotherapy and chemotherapyZhi Ji, Xia Wang, Jiaqi Xin, Lijun Ma, Duo Zuo, Hongli Li, Lan Su, Xinze Lv, Shaohua Ge, Le Zhang, Yong Liu, Yanhui Zhang, Tingting Ding, Ting Deng, Yi BaSee the full list of authors
9 December 2024
Novel tri-specific T-cell engager targeting IL-13Rα2 and EGFRvIII provides long-term survival in heterogeneous GBM challenge and promotes antitumor cytotoxicity with patient immune cellsDaniel H Park, Pratik S Bhojnagarwala, Kevin Liaw, Devivasha Bordoloi, Nicholas J Tursi, Shushu Zhao, Zev A Binder, Donald O’Rourke, David B Weiner
2 December 2024